CMT FACTS: Neurotoxic Drugs and CMT

Neurotoxins, substances that cause damage to nerves, act directly on individual nerve cells by interfering with membrane proteins. Overall, the effect of neurotoxins will depend on dosage, but typically results in loss of muscle control and/or feeling. For a person with CMT, this is extremely important. Symptoms can remain dormant, only to be severely increased by a neurotoxin. Prevention of progression should focus on avoiding drugs that can affect any pre-existing neurological disease, especially CMT. Medication toxicity is important to recognize when it occurs so that the offending agent can be discontinued, but when possible, preventing exposure to neurotoxic medications all together is preferable.

Principles for Dealing with Drugs and CMT Patients

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Dr. Louis J. Weimer, Clinical Professor of Neurology, Columbia University Medical Center. talks about the dangers and risks that Charcot-Marie-Tooth patients face from neurotoxic drugs.

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